5-Phenyl-4H-[1,2,4]triazole-3-carboxylic acid
5-Phenyl-4H-[1,2,4]triazole-3-carboxylic acid
CAS: 7200-46-6
Molecular Formula: C9H7N3O2
5-Phenyl-4H-[1,2,4]triazole-3-carboxylic acid - Names and Identifiers
5-Phenyl-4H-[1,2,4]triazole-3-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C9H7N3O2 |
| Molar Mass | 189.17 |
| Density | 1.432±0.06 g/cm3(Predicted) |
| Melting Point | 114 °C (decomp) |
| Boling Point | 482.8±28.0 °C(Predicted) |
| pKa | 3.14±0.10(Predicted) |
| Storage Condition | -20℃ |
| Sensitive | Irritant |
| MDL | MFCD16618449 |
5-Phenyl-4H-[1,2,4]triazole-3-carboxylic acid - Introduction
5-Phenyl-4H-[1,2,4]triazole-3-carboxylic acid is an organic compound with the chemical formula C10H7N3O2.
Its physical properties include:
Appearance: colorless crystal
Melting point: about 210-212°C
Solubility: Soluble in some organic solvents, such as ethanol, dichloromethane, etc.
5-Phenyl-4H-[1,2,4]triazole-3-carboxylic acid has a wide range of applications in chemical research and drug synthesis, and has the following uses:
1. pesticide synthesis: as an intermediate for synthetic pesticides, it can be used to synthesize some pesticides, herbicides and other pesticides.
2. drug synthesis: 5-Phenyl-4H-[1,2,4]triazole-3-carboxylic acid can be used to synthesize some bioactive molecules, such as antibacterial drugs, anti-tumor drugs, etc.
3. polymer materials: it can be used as an intermediate for the synthesis of polymer materials, used in the preparation of polymers, coatings, adhesives and so on.
Preparation method, 5-Phenyl-4H-[1,2,4]triazole-3-carboxylic acid preparation method has a variety of, one of the common method is through the condensation reaction synthesis. Specific steps include:
1. phenylhydrazine reacts with bromoacetic acid under alkaline conditions to generate phenyl-N-bromoacetohydrazide.
2. Reaction with dicyanamino acetic acid in the presence of NaOH to give 5-phenyl -4H-1,2,4-triazole.
3. Further reaction with acid to generate the final product 5-Phenyl-4H-[1,2,4]triazole-3-carboxylic acid.
Its physical properties include:
Appearance: colorless crystal
Melting point: about 210-212°C
Solubility: Soluble in some organic solvents, such as ethanol, dichloromethane, etc.
5-Phenyl-4H-[1,2,4]triazole-3-carboxylic acid has a wide range of applications in chemical research and drug synthesis, and has the following uses:
1. pesticide synthesis: as an intermediate for synthetic pesticides, it can be used to synthesize some pesticides, herbicides and other pesticides.
2. drug synthesis: 5-Phenyl-4H-[1,2,4]triazole-3-carboxylic acid can be used to synthesize some bioactive molecules, such as antibacterial drugs, anti-tumor drugs, etc.
3. polymer materials: it can be used as an intermediate for the synthesis of polymer materials, used in the preparation of polymers, coatings, adhesives and so on.
Preparation method, 5-Phenyl-4H-[1,2,4]triazole-3-carboxylic acid preparation method has a variety of, one of the common method is through the condensation reaction synthesis. Specific steps include:
1. phenylhydrazine reacts with bromoacetic acid under alkaline conditions to generate phenyl-N-bromoacetohydrazide.
2. Reaction with dicyanamino acetic acid in the presence of NaOH to give 5-phenyl -4H-1,2,4-triazole.
3. Further reaction with acid to generate the final product 5-Phenyl-4H-[1,2,4]triazole-3-carboxylic acid.
Last Update：2024-04-09 21:48:26
![5-Phenyl-4H-[1,2,4]triazole-3-carboxylic acid](http://res.chembk.com/assets/str/2d/7/72/7200-46-6.png)